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1

Effects of Antipsychotic Drugs onIto,INa,Isus,IK1, and hERG: QT Prolongation, Structure Activity Relationship, and Network Analysis

William J. Crumb, Sean Ekins, R. Dustan Sarazan, James H. Wikel, Steven A. Wrighton, Christopher Carlson, Charles M. Beasley

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 617 KB

english, 2006

2

The human drug metabolizing cytochromes P450

Steven A. Wrighton, Mark VandenBranden, Barbara J. Ring

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1996

Language:

english

File:

PDF, 682 KB

english, 1996

3

Progress in predicting human ADME parameters in silico

Sean Ekins, Chris L Waller, Peter W Swaan, Gabriele Cruciani, Steven A Wrighton, James H Wikel

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2000

Language:

english

File:

PDF, 1.26 MB

english, 2000

4

Application of in silico approaches to predicting drug–drug interactions

Sean Ekins, Steven A Wrighton

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2001

Language:

english

File:

PDF, 252 KB

english, 2001

5

In vitro-in vivo correlations of human (s)-nicotine metabolism

Clifford E. Berkman, Sang B. Park, Steven A. Wrighton, John R. Cashman

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 658 KB

english, 1995

6

The Human Hepatic Cytochromes P450 Involved in Drug Metabolism

Wrighton, Steven A., Stevens, Jeffrey C.

Journal:

Critical Reviews in Toxicology

Year:

1992

Language:

english

File:

PDF, 1.92 MB

english, 1992

7

Reopening Colleges and Universities During the COVID-19 Pandemic

Wrighton, Mark S., Lawrence, Steven J.

Journal:

Annals of Internal Medicine

Year:

2020

File:

PDF, 52 KB

2020

8

Metabolism of phenytoin by the gingiva of normal humans: The possible role of reactive metabolities of phenytoin in the initiation of gingival hyperplasia*

Zhou, Ling Xiang, Pihlstrom, Bruce, Hardwick, James P., Park, Sang S., Wrighton, Steven A., Holtzman, Jordan L.

Journal:

Clinical Pharmacology & Therapeutics

Year:

1996

Language:

english

File:

PDF, 913 KB

english, 1996

9

The effects of an oral contraceptive containing ethinyloestradiol and norgestrel on CYP3A activity

Donna J. Belle, John T. Callaghan, J. Christopher Gorski, Juan F. Maya, Omiema Mousa, Steven A. Wrighton, Stephen D. Hall

Journal:

British Journal of Clinical Pharmacology

Year:

2002

Language:

english

File:

PDF, 118 KB

english, 2002

10

Predictions of theIn VivoClearance of Drugs from Rate of Loss Using Human Liver Microsomes for Phase I and Phase II Biotransformations

Michael A. Mohutsky, Jenny Y. Chien, Barbara J. Ring, Steven A. Wrighton

Journal:

Pharmaceutical Research

Year:

2006

Language:

english

File:

PDF, 376 KB

english, 2006

11

Evaluation of anin vitrococulture model for the blood-brain barrier: Comparison of human umbilical vein endothelial cells (ECV304) and rat glioma cells (C6) from two commercial sources

Jamie L. Scism, Dennis A. Laska, Jeffrey W. Horn, Jerry L. Gimple, Susan E. Pratt, Robert L. Shepard, Anne H. Dantzig, Steven A. Wrighton

Journal:

In Vitro Cellular & Developmental Biology - Animal

Year:

1999

Language:

english

File:

PDF, 1.96 MB

english, 1999

12

Genomic analysis of the carboxylesterases: Identification and classification of novel forms

Eric T. Williams, He Wang, Steven A. Wrighton, Yue-Wei Qian, Everett J. Perkins

Journal:

Molecular Phylogenetics and Evolution

Year:

2010

Language:

english

File:

PDF, 2.03 MB

english, 2010

13

In vitro interaction of the antipsychotic agent olanzapine with human cytochromes P450 CYP2C9, CYP2C19, CYP2D6 and CYP3A

BARBARA J. RING, SHELLY N. BINKLEY, MARK VANDENBRANDEN, STEVEN A. WRIGHTON

Journal:

British Journal of Clinical Pharmacology

Year:

1996

Language:

english

File:

PDF, 666 KB

english, 1996

14

Desipramine, substrate for CYP2D6 activity: population pharmacokinetic model and design elements of drug–drug interaction trials

Ivelina Gueorguieva, Kimberley Jackson, Steven A. Wrighton, Vikram P. Sinha, Jenny Y. Chien

Journal:

British Journal of Clinical Pharmacology

Year:

2010

Language:

english

File:

PDF, 2.29 MB

english, 2010

15

Metabolic capabilities of cytochrome P450 enzymes in Chinese liver microsomes compared with those in Caucasian liver microsomes

Junling Yang, Minxia M. He, Wei Niu, Steven A. Wrighton, Li Li, Yang Liu, Chuan Li

Journal:

British Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 7.06 MB

english, 2012

16

10.1038/86882

Kuehl, Peter, Zhang, Jiong, Lin, Yvonne, Lamba, Jatinder, Assem, Mahfoud, Schuetz, John, Watkins, Paul B., Daly, Ann, Wrighton, Steven A., Hall, Stephen D., Maurel, Patrick, Relling, Mary, Brimer, Cyn

Journal:

Nature Genetics

Year:

2001

Language:

english

File:

PDF, 114 KB

english, 2001

17

Antitumor immune responses mediated by adenoviral GDEPT using nitroreductase/CB1954 is enhanced by high-level coexpression of heat shock protein 70

Djeha, Hakim A, Todryk, Stephen M, Pelech, Steven, Wrighton, Christopher J, Irvine, Alistair S, Mountain, Andrew, Lipinski, Kai S

Journal:

Cancer Gene Therapy

Year:

2005

Language:

english

File:

PDF, 312 KB

english, 2005

18

A Population Approach to Enzyme Characterization and Identification: Application to Phenacetin O-Deethylation

Donna J. Belle, Barbara J. Ring, Sandra R. B. Allerheiligen, Michael A. Heathman, Lisa M. O'Brien, Vikram Sinha, Lorin K. Roskos, Steven A. Wrighton

Journal:

Pharmaceutical Research

Year:

2000

Language:

english

File:

PDF, 168 KB

english, 2000

19

Inhibition of Human CYP3A Catalyzed 1′-Hydroxy Midazolam Formation by Ketoconazole, Nifedipine, Erythromycin, Cimetidine, and Nizatidine

Steven A. Wrighton, Barbara J. Ring

Journal:

Pharmaceutical Research

Year:

1994

File:

PDF, 661 KB

1994

20

The role of hepatic and extrahepatic UDP-glucuronosyltransferases in human drug metabolism*1†2

Fisher, Michael B., Paine, Mary F., Strelevitz, Timothy J., Wrighton, Steven A.

Journal:

Drug Metabolism Reviews

Year:

2001

Language:

english

File:

PDF, 321 KB

english, 2001

21

Effect of Taxol on Cytochrome P450 3A and Acetaminophen Toxicity in Cultured Rat Hepatocytes: Comparison to Dexamethasone

Vsevolod E. Kostrubsky, Lionel D. Lewis, Sheryl G. Wood, Peter R. Sinclair, Steven A. Wrighton, Jacqueline F. Sinclair

Journal:

Toxicology and Applied Pharmacology

Year:

1997

Language:

english

File:

PDF, 219 KB

english, 1997

22

Role of CYP3A in Ethanol-Mediated Increases in Acetaminophen Hepatotoxicity

Vsevolod E. Kostrubsky, Juliana G. Szakacs, Elizabeth H. Jeffery, Sheryl G. Wood, William J. Bement, Steven A. Wrighton, Peter R. Sinclair, Jacqueline F. Sinclair

Journal:

Toxicology and Applied Pharmacology

Year:

1997

Language:

english

File:

PDF, 1.11 MB

english, 1997

23

Effect of Arsenite on Induction of CYP1A, CYP2B, and CYP3A in Primary Cultures of Rat Hepatocytes

Judith M. Jacobs, Calen E. Nichols, Angeline S. Andrew, Doreen E. Marek, Sheryl G. Wood, Peter R. Sinclair, Steven A. Wrighton, Vsevolod E. Kostrubsky, Jacqueline F. Sinclair

Journal:

Toxicology and Applied Pharmacology

Year:

1999

Language:

english

File:

PDF, 183 KB

english, 1999

24

Short-term Treatment with Alcohols Causes Hepatic Steatosis and Enhances Acetaminophen Hepatotoxicity in Cyp2e1(-/-) Mice

Jacqueline F. Sinclair, Juliana G. Szakacs, Sheryl G. Wood, Heidi S. Walton, Jenna L. Bement, Frank J. Gonzalez, Elizabeth H. Jeffery, Steven A. Wrighton, William J. Bement, Peter R. Sinclair

Journal:

Toxicology and Applied Pharmacology

Year:

2000

Language:

english

File:

PDF, 668 KB

english, 2000

25

Effect of Caffeine on Acetaminophen Hepatotoxicity in Cultured Hepatocytes Treated with Ethanol and Isopentanol

Keith DiPetrillo, Sheryl Wood, Vsevolod Kostrubsky, Kathryn Chatfield, Jenna Bement, Steven Wrighton, Elizabeth Jeffery, Peter Sinclair, Jacqueline Sinclair

Journal:

Toxicology and Applied Pharmacology

Year:

2002

Language:

english

File:

PDF, 92 KB

english, 2002

26

Potentially increasing the metabolic stability of drug candidates via computational site of metabolism prediction by CYP2C9: The utility of incorporating protein flexibility via an ensemble of structures

Matthew L. Danielson, Prashant V. Desai, Michael A. Mohutsky, Steven A. Wrighton, Markus A. Lill

Journal:

European Journal of Medicinal Chemistry

Year:

2011

Language:

english

File:

PDF, 728 KB

english, 2011

27

Arsenite decreases CYP3A23 induction in cultured rat hepatocytes by transcriptional and translational mechanisms

Trisha L. Noreault, Judith M. Jacobs, Ralph C. Nichols, Heidi W. Trask, Steven A. Wrighton, Peter R. Sinclair, Ronald M. Evans, Jacqueline F. Sinclair

Journal:

Toxicology and Applied Pharmacology

Year:

2005

Language:

english

File:

PDF, 344 KB

english, 2005

28

Effect of proteasome inhibition on toxicity and CYP3A23 induction in cultured rat hepatocytes: Comparison with arsenite

Trisha L. Noreault-Conti, Judith M. Jacobs, Heidi W. Trask, Steven A. Wrighton, Jacqueline F. Sinclair, Ralph C. Nichols

Journal:

Toxicology and Applied Pharmacology

Year:

2006

Language:

english

File:

PDF, 708 KB

english, 2006

29

Effect of buffer components and carrier solvents on in vitro activity of recombinant human carboxylesterases

Eric T. Williams, Mariam E. Ehsani, Xiliang Wang, He Wang, Yue-Wei Qian, Steven A. Wrighton, Everett J. Perkins

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2008

Language:

english

File:

PDF, 804 KB

english, 2008

30

Stereoselective sulfoxidation of sulindac sulfide by flavin-containing monooxygenases: Comparison of human liver and kidney microsomes and mammalian enzymes

Mitchell A Hamman, Barbara D Haehner-Daniels, Steven A Wrighton, Allan E Rettie, Stephen D Hall

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 470 KB

english, 2000

31

Acetaminophen hepatotoxicity precipitated by short-term treatment of rats with ethanol and isopentanol: Protection by triacetyloleandomycin

Jacqueline F Sinclair, Juliana G Szakacs, Sheryl G Wood, Vsevolod E Kostrubsky, Elizabeth H Jeffery, Steven A Wrighton, William J Bement, Dane Wright, Peter R Sinclair

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 1.18 MB

english, 2000

32

Present and future in vitro approaches for drug metabolism

Sean Ekins, Barbara J. Ring, James Grace, Donna J. McRobie-Belle, Steven A. Wrighton

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2000

Language:

english

File:

PDF, 584 KB

english, 2000

33

Biosynthesis of drug glucuronides for use as authentic standards

Matthew G. Soars, Edward L. Mattiuz, David A. Jackson, Palaniappan Kulanthaivel, William J. Ehlhardt, Steven A. Wrighton

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2002

Language:

english

File:

PDF, 224 KB

english, 2002

34

A novel testosterone 6β-hydroxylase activity assay for the study of CYP3A-mediated metabolism, inhibition, and induction in vitro

Jessica L Fayer, David M Petullo, Barbara J Ring, Steven A Wrighton, Kenneth J Ruterbories

Journal:

Journal of Pharmacological and Toxicological Methods

Year:

2001

Language:

english

File:

PDF, 123 KB

english, 2001

35

Isolation and Characterization of Human Liver Cytochrome P450 2C19: Correlation between 2C19 and S-Mephenytoin 4′-Hydroxylation

S.A. Wrighton, J.C. Stevens, G.W. Becker, M. Vandenbranden

Journal:

Archives of Biochemistry and Biophysics

Year:

1993

File:

PDF, 649 KB

1993

36

Induction of Cytochrome P4503A by Taxol in Primary Cultures of Human Hepatocytes

Vsevolod E. Kostrubsky, Lionel D. Lewis, Stephen C. Strom, Sheryl G. Wood, Erin G. Schuetz, John D. Schuetz, Peter R. Sinclair, Steven A. Wrighton, Jacqueline F. Sinclair

Journal:

Archives of Biochemistry and Biophysics

Year:

1998

Language:

english

File:

PDF, 191 KB

english, 1998

37

Synthesis and degradation of 3-methylcholanthrene-inducible cytochromes P-450 and their mRNAs in primary monolayer cultures of adult rat hepatocytes

A.Ruth Steward, Steven A. Wrighton, David S. Pasco, John B. Fagan, Donna Li, Philip S. Guzelian

Journal:

Archives of Biochemistry and Biophysics

Year:

1985

Language:

english

File:

PDF, 2.29 MB

english, 1985

38

Purification and characterization of aldo-keto reductases from gerbil liver: Immunochemical evidence for related proteins in other mammalian species

David T. Molowa, Steven A. Wrighton, Philip S. Guzelian

Journal:

Archives of Biochemistry and Biophysics

Year:

1986

Language:

english

File:

PDF, 1.10 MB

english, 1986

39

Degradation of rat hepatic cytochrome P-450 heme by 3,5-dicarbethoxy-2, 6-dimethyl-4-ethyl-1,4-dihydropyridine to irreversibly bound protein adducts

Maria Almira Correia, Caroline Decker, Katsumi Sugiyama, Patricia Caldera, Lester Bornheim, Steven A. Wrighton, Allan E. Rettie, William F. Trager

Journal:

Archives of Biochemistry and Biophysics

Year:

1987

Language:

english

File:

PDF, 1.34 MB

english, 1987

40

Purification and characterization of ethanol-inducible human hepatic cytochrome P-450HLj

Steven A. Wrighton, Paul E. Thomas, Dene E. Ryan, Wayne Levin

Journal:

Archives of Biochemistry and Biophysics

Year:

1987

Language:

english

File:

PDF, 984 KB

english, 1987

41

Isolation and characterization of human fetal liver cytochrome P450HLp2: A third member of the P450III gene family

Steven A. Wrighton, Mark Vandenbranden

Journal:

Archives of Biochemistry and Biophysics

Year:

1989

Language:

english

File:

PDF, 1.52 MB

english, 1989

42

Degradation of rat liver cytochromes P450 3A after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: Characterization of the proteolytic system

Maria Almira Correia, Suzanne H. Davoll, Steven A. Wrighton, Paul E. Thomas

Journal:

Archives of Biochemistry and Biophysics

Year:

1992

Language:

english

File:

PDF, 2.61 MB

english, 1992

43

Differential apoprotein loss of rat liver cytochromes P450 after their inactivation by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine: A case for distinct proteolytic mechanisms?

Maria Almira Correia, Kunquan Yao, Steven A. Wrighton, David J. Waxman, Allan E. Rettie

Journal:

Archives of Biochemistry and Biophysics

Year:

1992

Language:

english

File:

PDF, 2.33 MB

english, 1992

44

Identification of a cytochrome P-450 in human fetal liver related to glucocorticoid-inducible cytochrome P-450HLp in the adult

Steven A. Wrighton, David T. Molowa, Philip S. Guzelian

Journal:

Biochemical Pharmacology

Year:

1988

Language:

english

File:

PDF, 431 KB

english, 1988

45

Modulation of the induction of rat hepatic cytochromes P-450 by selenium deficiency

Steven A. Wrighton, Barbara Elswick

Journal:

Biochemical Pharmacology

Year:

1989

Language:

english

File:

PDF, 457 KB

english, 1989

46

Distribution of cytochromes P-450, cytochrome b5, and nadph-cytochrome P-450 reductase in an entire human liver

Paul B. Watkins, Scott A. Murray, Paul E. Thomas, Steven A. Wrighton

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 678 KB

english, 1990

47

Modulation of rat hepatic cytochromes P450 by chronic methapyrilene treatment

Steven A. Wrighton, Mark Vandenbranden, Thomas J. Brown, Carolyn S. Van Pelt, Paul E. Thomas, Lisa A. Shipley

Journal:

Biochemical Pharmacology

Year:

1991

Language:

english

File:

PDF, 615 KB

english, 1991

48

Detection of human lung cytochromes P450 that are immunochemically related to cytochrome P450IIE1 and cytochrome P450IIIA

Clyde W. Wheeler, Steven A. Wrighton, Thomas M. Guenthner

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 486 KB

english, 1992

49

Characterization of dextromethorphan N-demethylation by human liver microsomes: Contribution of the cytochrome P450 3A (CYP3A) subfamily

J.Christopher Gorski, David R. Jones, Steven A. Wrighton, Stephen D. Hall

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 1.09 MB

english, 1994

50

Role of cytochrome P450 2C9 and an allelic variant in the 4′-hydroxylation of (R)- and (S)-flurbiprofen

Timothy S. Tracy, Brady W. Rosenbluth, Steven A. Wrighton, Frank J. Gonzalez, Kenneth R. Korzekwa

Journal:

Biochemical Pharmacology

Year:

1995

Language:

english

File:

PDF, 702 KB

english, 1995